Journal article
Genome-wide DNA methylation assessment of ‘BRCA1-like’ early-onset breast cancer: Data from the Australian Breast Cancer Family Registry
CM Scott, EM Wong, JHE Joo, PA Dugué, CH Jung, N O'Callaghan, J Dowty, GG Giles, JL Hopper, MC Southey
Experimental and Molecular Pathology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2018
Abstract
Breast cancers arising in women carrying a germline mutation in BRCA1 are typically high-grade, early-onset and have distinct morphological features (BRCA1-like). However, the majority of early-onset breast cancers of this morphological type are not associated with germline BRCA1 mutations or constitutional BRCA1 promoter methylation. We aimed to assess DNA methylation across the genome for associations with the “BRCA1-like” morphology. Genome-wide methylation in blood-derived DNA was measured using the Infinium HumanMethylation450K BeadChip assay for women under the age of 40 years participating in the Australian Breast Cancer Family Study (ABCFS) diagnosed with: i) BRCA1-like breast cancer..
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Awarded by National Cancer Institute
Funding Acknowledgements
The Australia site of Breast Cancer Family Registry was supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation (Australia) and grant UM1 CA164920 from the USA National Cancer Institute. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR. JLH is a Senior Principle Research Fellow of the NHMRC and MCS is a Senior Research Fellow. CMS was a recipient of a Genetic Epidemiology Laboratory Honours Scholarship, Department of Pathology, The University of Melbourne.